I've never had the issue that some guys do, and I ran a mix - from bug wash to ~80% meth. Two guys I know with 100% alky had their intakes backfire, one ran a SMIM. That said I do agree...I haven't come across a SMIM blown open on a mix which is what led me to wonder why that is.
I think the injectors need to batch fire to ensure enough open time, definitely.
The ignition time might be the opposite. The coils need time to charge so having a sequential or direct fire ignition should give them that extra 720*. However the stock ignition coils have more than enough power to fire off both plugs and still ignite the charge on half the time. That's due to the 'wasted cylinder' not requiring much energy and it firing with reversed polarity (side to centre vs centre to side electrode).
BTW that last comment is why platinum plugs work like ass in any waste spark design. It operates the plug in reverse of its design half of the time. Buying double-platinum works, or iridium IIRC.
I'd love to find out if there would be enough of a chance in having the meth;
1. go through the opening intake valve on the 'fresh' cylinder,
2. become ignited by the weak wasted spark during the intake event,
3. and not get carried through the exhaust scavenging but rather revert back up into the intake.
I think for htat to happen you'd need much more pressure on the exh side than on the intake which may require closing the throttle (back to my original question). I do know that if you had no overlap this might be more of a problem (exh valves closed, intake open & spark ignites the meth on the upstroke of the piston). In that scenario closing the throttle to get vacuum in the intake might pull that charge back up through the manifold.
again, just supposing...